PoL – Physics of Life | Vision and Research Avenues

Research Avenue 7

Bio-Data Science and Physics-Inspired AI

Data-analysis and computational modeling play a fundamental role in linking theory and experiment. They help to generate testable hypotheses, interpret experimental data, study nonlinear models and are essential for testing the adequacy of physical theories. We envision novel computational methods, often based on AI algorithms, that are required to extract hidden patterns from data in the non-equilibrium, nonlinear, and multiscale systems studied at PoL.

Our aim will be to develop novel data analysis, Machine Learning, and scientific computing methods, with a focus on algorithmic innovations designed from the ground up, to cope with the complexity of living systems. We will integrate theory-driven numerical simulations with data-driven inference, resulting in physics-informed bio-data science. The mathematical foundations of topological data analysis will also be expanded, and used to understand these systems.

Research Topic 1

Revealing the High-Order Structures of Discrete Biological Data

Research Topic 2

Deep Learning for Biomolecular Grammar

Research Topic 3

Data-driven Modeling and Simulation

Research Topic 4

Bio-image Artificial Intelligence

RA Leading Team

Ivo F. Sbalzarini
(RA Leader)

TUD, CSBD | Professor for Scientific Computing for Systems Biology

The MOSAIC Group: Scientific Computing for Image-based Systems Biology

›› open the website of Ivo F. Sbalzarini<br>(RA Leader) in a new tab

© MPI-CBG

Heather Harrington
(RA Co-Leader)

MPI-CBG, CSBD | Director of MPI-CBG and CSBD, Professor of Mathematics at the Mathematical Institute, University of Oxford

Algebraic Systems Biology

›› open the website of Heather Harrington<br>(RA Co-Leader) in a new tab

© Z Goriely

Ágnes Tóth-Petróczy

MPI-CBG | Research Group Leader

Protein plasticity and evolution

›› open the website of Ágnes Tóth-Petróczy in a new tab

© MPI-CBG

PoL Groups

Simon Alberti

TUD BIOTEC | Professor for Cellular Biochemistry

Organization of cytoplasm across space and time

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© MPI-CBG

Ricard Alert

MPI-PKS, CSBD | Research Group Leader

The Physics of Living Matter

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© MPI-CBG

Otger Campàs

Chair of Tissue Dynamics

Physics of Embryonic Self-Organization and Morphogenesis

hired by PoL

›› visit the website of Otger Campàs

Adele Doyle

Research Group Leader

Mechanobiology of Stem Cells

hired by PoL

›› visit the website of Adele Doyle

Benjamin Friedrich

Heisenberg Professor for Biological Algorithms

Biological Algorithms: Spatio-Temporal Dynamics of Cells and Tissues

hired by PoL

›› visit the website of Benjamin Friedrich

Anne Grapin-Botton

MPI-CBG | Director of MPI-CBG

Self-organization of cells into organ communities

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© MPI-CBG

Stephan W. Grill

MPI-CBG | Director of MPI-CBG, Professor for Physics of Life

Physics of Life

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© MPI-CBG

Heather Harrington

MPI-CBG, CSBD | Director of MPI-CBG and CSBD, Professor of Mathematics at the Mathematical Institute, University of Oxford

Algebraic Systems Biology

›› open the website of Heather Harrington in a new tab

© Z Goriely

Alf O. Honigmann

TUD BIOTEC | Professor for Biophysics

Membrane Organization of Cells and Tissues

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Meritxell Huch

MPI-CBG | Director of MPI-CBG, Lise Meitner Max Planck Research Group Leader

Organoids, tissue regeneration and its deregulation in disease

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© MPI-CBG

Anthony A. Hyman

MPI-CBG | Director of MPI-CBG, Professor for Molecular Cell Biology

Organization of Cytoplasm

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© Sven Döring

Frank Jülicher

MPI-PKS | Director of MPI-PKS, Professor for Biophysics

Dynamic processes in cells and tissues

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© MPI-CBG

Christina Kurzthaler

MPI-PKS, CSBD | Research Group Leader

Transport and Flows in Complex Environments

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© MPI-CBG

Ivo F. Sbalzarini

TUD, CSBD | Professor for Scientific Computing for Systems Biology

The MOSAIC Group: Scientific Computing for Image-based Systems Biology

›› open the website of Ivo F. Sbalzarini in a new tab

© MPI-CBG

Marc Timme

TUD | Professor for Network Dynamics

Network Dynamics

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Ágnes Tóth-Petróczy

MPI-CBG | Research Group Leader

Protein plasticity and evolution

›› open the website of Ágnes Tóth-Petróczy in a new tab

© MPI-CBG

Xingbo Yang

Research Group Leader

Bioenergetics of Self-Organization

hired by PoL

›› visit the website of Xingbo Yang

Associates and Affiliates

Anna Poetsch

TUD BIOTEC, NCT, CSBD | Research Group Leader

Biomedical Genomics

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Pavel Tomancak

MPI-CBG | Research Group Leader

Patterns of gene expression in animal development

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© MPI-CBG

Axel Voigt

TUD | Professor for Scientific Computing and Applied Mathematics

Mathematical Modeling and Numerical Simulation of Cells and Systems

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© MPI-CBG

Alexander von Appen

MPI-CBG | Research Group Leader

Structural Self-Organization of Membranous Organelles

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© MPI-CBG