PoL – Physics of Life | Vision and Research Avenues

Research Avenue 5

Physical Measurements in Intact Living Systems

Identifying physical principles of spatiotemporal self-organization in living cells and tissues requires quantitative measurements of key physical quantities. Currently, progress is limited by our ability to perform accurate measurements of physical quantities in a controlled and minimally invasive way within living systems. The development of new measurement techniques will bring our understanding of the physical basis of life to a new level.

Our aim is to develop technologies, or extend existing ones, that enable measurements of physical quantities that cannot currently be measured inside intact living systems. This includes electrical fields, material properties, mechanical stresses, osmotic and hydrostatic pressures, and flows of matter and energy. Additionally, we will develop smart robotic microscopy methods and AI-based approaches to perform high-throughput measurements of distributions of fluctuating physical quantities in intact cells, tissues and organisms.

Research Topic 1

Quantifying Rates and Flows in Living Matter

Research Topic 2

Revealing Energetics in Space and Time

Research Topic 3

Mechanical and Electrical Measurements Across Scales

Research Topic 4

A Robotic Lab for Generating Large Datasets

RA Leading Team

Stephan W. Grill
(RA Leader)

MPI-CBG | Director of MPI-CBG, Professor for Physics of Life

Physics of Life

›› open the website of Stephan W. Grill<br>(RA Leader) in a new tab

© MPI-CBG

Elisabeth Fischer-Friedrich
(RA Co-Leader)

Heisenberg Professor for Mechanics of Active Biomaterials

Mechanics of Active Biomaterials

hired by PoL

›› visit the website of Elisabeth Fischer-Friedrich<br>(RA Co-Leader)

Elias Barriga

Research Group Leader

Biophysical Mechanisms of Morphogenesis

hired by PoL

›› visit the website of Elias Barriga

Carsten Werner

IPF | Professor for Biofunctional Polymer Materials

Biofunctional polymer materials

›› open the website of Carsten Werner in a new tab

PoL Groups

Ellen Adams

Research Group Leader

Physical Chemistry of Biomolecular Condensates

hired by PoL

›› visit the website of Ellen Adams

Elias Barriga

Research Group Leader

Biophysical Mechanisms of Morphogenesis

hired by PoL

›› visit the website of Elias Barriga

Michael Brand

TUD CRTD | Professor for Developmental Genetics

Development and Regeneration of the Vertebrate Brain

›› open the website of Michael Brand in a new tab

Jan Brugués

Chair of Spatiotemporal Organization of Subcellular Structures

Spatiotemporal Organization of Subcellular Structures

hired by PoL

›› visit the website of Jan Brugués

Otger Campàs

Chair of Tissue Dynamics

Physics of Embryonic Self-Organization and Morphogenesis

hired by PoL

›› visit the website of Otger Campàs

Christian Dahmann

TUD | Professor for Systems Biology and Genetics

Signals and mechanics in epithelial morphogenesis

›› open the website of Christian Dahmann in a new tab

Stefan Diez

TUD B CUBE | Professor for BioNano Tools

Molecular transport in cell biology and nanotechnology

›› open the website of Stefan Diez in a new tab

© TUD CMCB, Magdalena Gonciarz

Miki Ebisuya

Humboldt Professor and Chair of Cell and Tissue Control

Cross-Species Comparison and Manipulation of the Organoid Zoo

hired by PoL

›› visit the website of Miki Ebisuya

Elisabeth Fischer-Friedrich

Heisenberg Professor for Mechanics of Active Biomaterials

Mechanics of Active Biomaterials

hired by PoL

›› visit the website of Elisabeth Fischer-Friedrich

Stephan W. Grill

MPI-CBG | Director of MPI-CBG, Professor for Physics of Life

Physics of Life

›› open the website of Stephan W. Grill in a new tab

© MPI-CBG

Marcus Jahnel

Research Group Leader

Dynamics of Biomolecules

hired by PoL

›› visit the website of Marcus Jahnel

Rita Mateus

Research Group Leader

Biophysical Principles of Vertebrate Growth

hired by PoL

›› visit the website of Rita Mateus

Ivo F. Sbalzarini

TUD, CSBD | Professor for Scientific Computing for Systems Biology

The MOSAIC Group: Scientific Computing for Image-based Systems Biology

›› open the website of Ivo F. Sbalzarini in a new tab

© MPI-CBG

Michael Schlierf

TUD B CUBE | Professor for Molecular Biophysics

Conformational changes in biomolecules and enzymes

›› open the website of Michael Schlierf in a new tab

© TUD CMCB, Magdalena Gonciarz

Carsten Werner

IPF | Professor for Biofunctional Polymer Materials

Biofunctional polymer materials

›› open the website of Carsten Werner in a new tab

Xingbo Yang

Research Group Leader

Bioenergetics of Self-Organization

hired by PoL

›› visit the website of Xingbo Yang

Associates and Affiliates

Jonathan Rodenfels

MPI-CBG | Research Group Leader

Energetics of Biological Systems

›› open the website of Jonathan Rodenfels in a new tab

© MPI-CBG

Pavel Tomancak

MPI-CBG | Research Group Leader

Patterns of gene expression in animal development

›› open the website of Pavel Tomancak in a new tab

© MPI-CBG

Jesse Veenvliet

MPI-CBG | Research Group Leader

Stembryogenesis

›› open the website of Jesse Veenvliet in a new tab

© MPI-CBG