Research Avenue 5

Scientific Computing and Systems Microscopy

RA5 will provide the required advances in computational approaches and interactive interrogation of biological systems. We will develop methodologies that enable quantitative predictions of spatiotemporal dynamics, interactively perturb samples, and test theories using a novel generation of computer simulation methods integrated with immersive, smart microscopes. Is a novel theory of an active process sufficient to explain certain emergent properties? How can we infer physically consistent models from data by combining information from different scales? How can we reliably automate the recording, visualization, and quantification of 3D spatiotemporal dynamics in a microscope, to generated the throughput necessary for quantifying biological processes with significant statistics? Which information about physical properties of biological matter can be measured by optical means in a spatially resolved way? Can we enable direct observation of physical mechanisms by rendering 3D microscopy interactive and immersive? Through answering these questions, we will advance computer science and microscopy to a level that allows automated, tailored, immersive and interactive studies of biological systems and testing of the mechanisms of spatiotemporal self-organization in vivo and in silico.

Research Avenue Leader

Ivo F. Sbalzarini

TUD, CSBD | Professor for Scientific Computing for Systems Biology

The MOSAIC Group: Scientific Computing for Image-based Systems Biology

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PoL Groups

Elias Barriga

Research Group Leader

Biophysical Mechanisms of Morphogenesis

hired by PoL

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Michael Brand

TUD CRTD | Professor for Developmental Genetics

Development and Regeneration of the Vertebrate Brain

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Jan Brugués

Chair of Spatiotemporal Organization of Subcellular Structures

Spatiotemporal Organization of Subcellular Structures

hired by PoL

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Otger Campàs

Chair of Tissue Dynamics

Physics of Embryonic Self-Organization and Morphogenesis

hired by PoL

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Raimund Dachselt

TUD | Professor for Multimedia Technology

Immersive Exploration of Multiscale Biological Data

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Stefan Diez

TUD B CUBE | Professor for BioNano Tools

Molecular transport in cell biology and nanotechnology

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Natalie Dye

Research Group Leader

Biophysics of Epithelial Growth and Tumorigenesis

hired by PoL

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Eugene W. Myers

CSBD | Professor for Computational Molecular Biology

Exploring Cells & Systems via Image Analysis and Customized Microscopy

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Ivo F. Sbalzarini

TUD, CSBD | Professor for Scientific Computing for Systems Biology

The MOSAIC Group: Scientific Computing for Image-based Systems Biology

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Michael Schlierf

TUD B CUBE | Professor for Molecular Biophysics

Conformational changes in biomolecules and enzymes

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Marc Timme

TUD | Professor for Network Dynamics

Network Dynamics

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Xingbo Yang

Research Group Leader

Bioenergetics of Self-Organization

hired by PoL

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Associates and Affiliates

Jürgen Czarske

TUD | Professor for Measurement and Sensor Systems

Biomedical Computational Laser Systems (BIOLAS): Adaptive Smart Microscopy

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Stefan Gumhold

TUD | Professor for Computer Graphics and Visualization

Computer Graphics and Visualization

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Wolfgang Lehner

TUD | Professor for Database Systems

Dresden Database Systems Group

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Carl Modes

MPI-CBG | Research Group Leader

Network Complexity and Systems Biophysics

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Arash Nikoubashman

IPF, TUD Faculty of Physics | Heisenberg Professor for Theory of Biologically Inspired Polymers

Theory of Bio-inspired polymers

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Anna Poetsch

TUD BIOTEC, NCT, CSBD | Research Group Leader

Biomedical Genomics

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Marko Popović

MPI-PKS, CSBD | Research Group Leader

Order and disorder in driven systems

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Pavel Tomancak

MPI-CBG | Research Group Leader

Patterns of gene expression in animal development

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Jesse Veenvliet

MPI-CBG | Research Group Leader

Stembryogenesis

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Axel Voigt

TUD | Professor for Scientific Computing and Applied Mathematics

Mathematical Modeling and Numerical Simulation of Cells and Systems

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Christoph Zechner

MPI-CBG | Research Group Leader

Adaptive Biosystems

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