Dr. Maria Rostovskaya: Pluripotent stem cells to solve the enigmas of human development and evolution of embryogenesis

CRTD: front and main entrance of the building as seen from the parking lot

Human peri-implantation development remains a black box of developmental biology, as embryos at this stage are practically inaccessible for studies due to the ethical considerations. Moreover, we learn only little using conventional model organisms such as mouse, because early human development strikingly differs in terms of timing, morphology and signalling cues. In my previous work, I established an in vitro experimental system using human pluripotent stem cells that closely recapitulates peri-implantation period of epiblast development. This system allows to model the distinct features of human early embryo development closely reproducing temporal, transcriptional and morphological characteristics, including formation of three-dimensional structures. Understanding these processes also reveals how these human-specific features of embryogenesis evolved during the evolution.
Most important recent publications:

  • Rostovskaya M*, Andrews S, Reik W*, Rugg-Gunn PJ*. Amniogenesis occurs in two independent waves in primate embryos. In revision (as in December 2021) (*co-corresponding authors)
  • Rostovskaya M*, Stirparo G, Smith A*. Capacitation of human naïve pluripotent stem cells for multi-lineage differentiation. Development. 2019; 146: 1-15. (*co-corresponding authors)
  • Rostovskaya M*, Donsanthe S, Sacchetti B, Alexopoulou D, Klemroth S, Dahl A, Riminucci M, Bianco P and Anastassiadis K*. Clonal analysis delineates transcriptional programs of osteogenic and adipogenic lineages of adult mouse skeletal progenitors. Stem Cell Reports. 2018; 11 (1): 212-227. (*co-corresponding authors)
  • Rostovskaya M, Bredenkamp N, Smith AG. Towards consistent generation of pancreatic lineage progenitors from human pluripotent stem cells. Philos. Trans. R. Soc. B. 2015; 370: 20140365.
  • Rostovskaya M, Fu J, Obst M, Baer I, Weidlich S, Wang H, Smith AJ, Anastassiadis K, Stewart AF. Transposon-mediated BAC transgenesis in human ES cells. Nucleic Acids Res. 2012; 40(19): e150.

After the talk our Speaker will be available for one-to-one chats.
If you would like to exchange some scientific thoughts with her, please contact directly the host – Konstantinos Anastassiadis (konstantinos.anastassiadis@tu-dresden.de).

Please find further info on the webiste of the organizer, the CMCB (TU Dresden).