PoL – Physics of Life | Vision and Research Avenues

Research Avenue 5

Scientific Computing and Systems Microscopy

RA5 will provide the required advances in computational approaches and interactive interrogation of biological systems. We will develop methodologies that enable quantitative predictions of spatiotemporal dynamics, interactively perturb samples, and test theories using a novel generation of computer simulation methods integrated with immersive, smart microscopes. Is a novel theory of an active process sufficient to explain certain emergent properties? How can we infer physically consistent models from data by combining information from different scales? How can we reliably automate the recording, visualization, and quantification of 3D spatiotemporal dynamics in a microscope, to generated the throughput necessary for quantifying biological processes with significant statistics? Which information about physical properties of biological matter can be measured by optical means in a spatially resolved way? Can we enable direct observation of physical mechanisms by rendering 3D microscopy interactive and immersive? Through answering these questions, we will advance computer science and microscopy to a level that allows automated, tailored, immersive and interactive studies of biological systems and testing of the mechanisms of spatiotemporal self-organization in vivo and in silico.

Research Avenue Leader

Research Avenue 5 RA1 RA4 RA6

Ivo F. Sbalzarini

TUD, CSBD | Professor for Scientific Computing for Systems Biology

The MOSAIC Group: Scientific Computing for Image-based Systems Biology

›› visit the website of Ivo F. Sbalzarini

Core Groups

Research Avenue 1 RA3 RA4 RA5 RA6

Otger Campàs Group

Physics of Embryonic Self-Organization and Morphogenesis

Chair of Tissue Dynamics

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Research Avenue 1 RA4 RA5

Natalie Dye Group

Biophysics of epithelial growth and tumorigenesis

Research Group Leader

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Research Avenue 5

Bio-image Analysis

Group Leader: Robert Haase

Technology Development Group Leader

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Research Avenue 5

Optical Microscopy

Group Leader: Bert Nitzsche

Technology Development Group Leader

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Associates and Affiliates

Research Avenue 1 RA4 RA5 RA6

Michael Brand Group

TUD CRTD | Professor for Developmental Genetics

Development and Regeneration of the Vertebrate Brain

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Research Avenue 5 RA1 RA6

Jürgen Czarske Group

TUD | Professor for Measurement and Sensor Systems

Biomedical Computational Laser Systems (BIOLAS): Adaptive Smart Microscopy

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© Center BIOLAS, TUD

Research Avenue 5 RA6

Raimund Dachselt Group

TUD | Professor for Multimedia Technology

Immersive Exploration of Multiscale Biological Data

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Research Avenue 3 RA2 RA5 RA6

Stefan Diez Group

TUD B CUBE | Professor for BioNano Tools

Molecular transport in cell biology and nanotechnology

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Research Avenue 5 RA6

Stefan Gumhold Group

TUD | Professor for Computer Graphics and Visualization

Computer Graphics and Visualization

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Research Avenue 5

Michael Hiller Group

MPI-PKS, MPI-CBG | Research Group Leader

Computational Biology and Evolutionary Genomics: Discovering phenotype-genotype associations

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Research Avenue 5 RA1 RA4

Moritz Kreysing Group

MPI-CBG | Research Group Leader

Biophotonics and self-organization

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Research Avenue 5

Wolfgang Lehner Group

TUD | Professor for Database Systems

Dresden Database Systems Group

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© TUD, Michael Kretzschmar

Research Avenue 4 RA1 RA5 RA6

Carl Modes Group

MPI-CBG | Research Group Leader

Network Complexity and Systems Biophysics

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Research Avenue 5 RA4

Eugene W. Myers Group

CSBD | Director of MPI-CBG, Professor for Computational Molecular Biology

Exploring Cells & Systems via Image Analysis and Customized Microscopy

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Research Avenue 5 RA1 RA4 RA6

Ivo F. Sbalzarini Group

TUD, CSBD | Professor for Scientific Computing for Systems Biology

The MOSAIC Group: Scientific Computing for Image-based Systems Biology

›› visit the website of Ivo F. Sbalzarini Group

Research Avenue 3 RA2 RA5 RA6

Michael Schlierf Group

TUD B CUBE | Professor for Molecular Biophysics

Conformational changes in biomolecules and enzymes

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Research Avenue 4 RA2 RA5

Marc Timme Group

TUD | Professor for Network Dynamics

Network Dynamics

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Research Avenue 1 RA5

Pavel Tomancak Group

MPI-CBG | Research Group Leader

Patterns of gene expression in animal development

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Research Avenue 5 RA1 RA2 RA3 RA4

Axel Voigt Group

TUD | Professor for Scientific Computing and Applied Mathematics

Mathematical Modeling and Numerical Simulation of Cells and Systems

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Research Avenue 2 RA4 RA5 RA6

Christoph Zechner Group

MPI-CBG | Research Group Leader

Adaptive Biosystems

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