PoL – Physics of Life | Vision and Research Avenues

Research Avenue 2

Compartmentalization of Living Matter

RA2 wants to understand the extent to which the principles of phase separation and phase transitions help in understanding how cells modulate their biochemistry. We aim to have a general understanding of the ways in which phase separation and cellular compartments emerge from physical chemistry and the interaction of individual molecules. How are cellular compartments organized in space and time? How is phase separation and phase transitions controlled inside the cell? How does the cytoskeleton guide compartment formation inside cells? How do protein drops wet cytoskeletal filaments and cell membranes? How do single molecules behave as they form protein droplets? How can active matter physics contribute to our understanding of phase separation of biological molecules? To answer these questions, we will strengthen the current approaches in Dresden by establishing a program in physical chemistry to study the molecular grammar driving phase separation and compositional specificity of cellular condensates.

Research Avenue Leader

Research Avenue 2

Anthony A. Hyman

MPI-CBG | Director of MPI-CBG, Professor for Molecular Cell Biology

Organization of Cytoplasm

›› visit the website of Anthony A. Hyman

© Tristan Vostry

Core Groups

Research Avenue 4 RA1 RA2 RA3

Benjamin Friedrich Group

Biological Algorithms: Spatio-temporal dynamics of cells and tissues

Heisenberg Professor for Biological Algorithms

›› visit the website of Benjamin Friedrich Group

© cfaed, Katharina Knaut

Research Avenue 3 RA2

Marcus Jahnel Group

Dynamics of Biomolecules

Research Group Leader

›› visit the website of Marcus Jahnel Group

© Mark Leaver

Associates and Affiliates

Research Avenue 2 RA3 RA6

Simon Alberti Group

TUD BIOTEC | Professor for Cellular Biochemistry

Organization of cytoplasm across space and time

›› visit the website of Simon Alberti Group

Research Avenue 2 RA1 RA3 RA6

Jan Brugués Group

MPI-PKS, MPI-CBG | Research Group Leader

Self-organization of biological structures

›› visit the website of Jan Brugués Group

Research Avenue 3 RA2 RA5 RA6

Stefan Diez Group

TUD B CUBE | Professor for BioNano Tools

Molecular transport in cell biology and nanotechnology

›› visit the website of Stefan Diez Group

Research Avenue 2 RA3

Karim Fahmy Group

HZDR | Head of the Biophysics Division

Structural basis of biological switches and biomolecular recognition

›› visit the website of Karim Fahmy Group

Research Avenue 3 RA1 RA2 RA4

Stephan W. Grill Group

MPI-CBG | Director of MPI-CBG, Professor for Biophysics

Physics of Life

›› visit the website of Stephan W. Grill Group

Research Avenue 1 RA2 RA3 RA6

Alf O. Honigmann Group

MPI-CBG | Research Group Leader

Membrane Organization of Cells and Tissues

›› visit the website of Alf O. Honigmann Group

Research Avenue 2

Anthony A. Hyman Group

MPI-CBG | Director of MPI-CBG, Professor for Molecular Cell Biology

Organization of Cytoplasm

›› visit the website of Anthony A. Hyman Group

© Tristan Vostry

Research Avenue 4 RA2 RA3

Nils Kröger Group

TUD B CUBE | Professor for Biomimetic Materials

From Molecular Mechanisms of Biomineralization and Bioadhesion to Applications in Nanobiotechnology

›› visit the website of Nils Kröger Group

Research Avenue 3 RA2 RA5 RA6

Michael Schlierf Group

TUD B CUBE | Professor for Molecular Biophysics

Conformational changes in biomolecules and enzymes

›› visit the website of Michael Schlierf Group

Research Avenue 2 RA3

Michele Solimena Group

TUD PLID, HMGU | Professor for Molecular Diabetology

Cell Biology of Pancreatic Beta Cells

›› visit the website of Michele Solimena Group

Research Avenue 3 RA2

Jens-Uwe Sommer Group

IPF | Professor for Theory of Polymers at Interfaces

Theoretical Polymer Physics

›› visit the website of Jens-Uwe Sommer Group

© IPF, Jürgen Lösel

Research Avenue 2 RA3 RA4 RA6

Dora Tang Group

MPI-CBG | Research Group Leader

Dynamic protocellular systems

›› visit the website of Dora Tang Group

Research Avenue 4 RA2 RA5

Marc Timme Group

TUD | Professor for Network Dynamics

Network Dynamics

›› visit the website of Marc Timme Group

Research Avenue 2 RA3

Ágnes Tóth-Petróczy Group

MPI-CBG | Research Group Leader

Protein plasticity and evolution

›› visit the website of Ágnes Tóth-Petróczy Group

Research Avenue 5 RA1 RA2 RA3 RA4

Axel Voigt Group

TUD | Professor for Scientific Computing and Applied Mathematics

Mathematical Modeling and Numerical Simulation of Cells and Systems

›› visit the website of Axel Voigt Group

Research Avenue 2 RA4 RA5 RA6

Christoph Zechner Group

MPI-CBG | Research Group Leader

Adaptive Biosystems

›› visit the website of Christoph Zechner Group

Research Avenue 2 RA1 RA3 RA6

Yixin Zhang Group

TUD B CUBE | Professor for Biomolecular Interaction

Drug design and screening: from biochemical methods to 3D model system

›› visit the website of Yixin Zhang Group