PoL – Physics of Life | Vision and Research Avenues

Research Avenue 1

Guided Mechanochemical Self-Organization

RA1 wants to unravel the principles by which mechanics and biochemical coupled in morphogenesis. We aim to reveal how the associated modules of self-organization are guided by physical cues and upstream signaling pathways. What are the mechanisms driving symmetry breaking in tissues and organisms? How do tissues size and shape themselves? How are tissue patterns generated and maintained? How are proportions maintained during growth? What makes a tissue fluid, what makes it contract? How do tissues buckle; how do they form three-dimensional shapes? What is the role of the Extracellular Matrix (ECM) in tissue morphogenesis? To address these questions, we will synergize our expertise in model organisms and organoids to identify modules of self-organisation and mechanisms of guidance by physical and anatomical cues, as well as singling pathways.

Research Avenue Leader

Research Avenue 1

Anne Grapin-Botton

MPI-CBG | Director of MPI-CBG

Self-organization of cells into organ communities

›› visit the website of Anne Grapin-Botton

Core Groups

Research Avenue 1 RA3 RA4 RA5 RA6

Otger Campàs Group

Physics of Embryonic Self-Organization and Morphogenesis

Chair of Tissue Dynamics

›› visit the website of Otger Campàs Group

Research Avenue 1 RA6

Adele Doyle Group

Mechanobiology of Stem Cells

Research Group Leader

›› visit the website of Adele Doyle Group

Research Avenue 1 RA4 RA5

Natalie Dye Group

Biophysics of epithelial growth and tumorigenesis

Research Group Leader

›› visit the website of Natalie Dye Group

Research Avenue 3 RA1 RA4 RA6

Elisabeth Fischer-Friedrich Group

Mechanics of active biomaterials

Research Group Leader

›› visit the website of Elisabeth Fischer-Friedrich Group

© BIOTEC

Research Avenue 4 RA1 RA2 RA3

Benjamin Friedrich Group

Biological Algorithms: Spatio-temporal dynamics of cells and tissues

Heisenberg Professor for Biological Algorithms

›› visit the website of Benjamin Friedrich Group

© cfaed, Katharina Knaut

Research Avenue 1

Rita Mateus Group

Biophysical Principles of Vertebrate Growth

Research Group Leader

›› visit the website of Rita Mateus Group

Associates and Affiliates

Research Avenue 1 RA4 RA5 RA6

Michael Brand Group

TUD CRTD | Professor for Developmental Genetics

Development and Regeneration of the Vertebrate Brain

›› visit the website of Michael Brand Group

Research Avenue 2 RA1 RA3 RA6

Jan Brugués Group

MPI-PKS, MPI-CBG | Research Group Leader

Self-organization of biological structures

›› visit the website of Jan Brugués Group

Research Avenue 5 RA1 RA6

Jürgen Czarske Group

TUD | Professor for Measurement and Sensor Systems

Biomedical Computational Laser Systems (BIOLAS): Adaptive Smart Microscopy

›› visit the website of Jürgen Czarske Group

© Center BIOLAS, TUD

Research Avenue 1 RA3 RA6

Christian Dahmann Group

TUD | Professor for Systems Biology and Genetics

Signals and mechanics in epithelial morphogenesis

›› visit the website of Christian Dahmann Group

Research Avenue 1

Anne Grapin-Botton Group

MPI-CBG | Director of MPI-CBG

Self-organization of cells into organ communities

›› visit the website of Anne Grapin-Botton Group

Research Avenue 3 RA1 RA2 RA4

Stephan W. Grill Group

MPI-CBG | Director of MPI-CBG, Professor for Biophysics

Physics of Life

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Research Avenue 1 RA2 RA3 RA6

Alf O. Honigmann Group

MPI-CBG | Research Group Leader

Membrane Organization of Cells and Tissues

›› visit the website of Alf O. Honigmann Group

Research Avenue 5 RA1 RA4

Moritz Kreysing Group

MPI-CBG | Research Group Leader

Biophotonics and self-organization

›› visit the website of Moritz Kreysing Group

Research Avenue 4 RA1 RA5 RA6

Carl Modes Group

MPI-CBG | Research Group Leader

Network Complexity and Systems Biophysics

›› visit the website of Carl Modes Group

Research Avenue 5 RA1 RA4 RA6

Ivo F. Sbalzarini Group

TUD, CSBD | Professor for Scientific Computing for Systems Biology

The MOSAIC Group: Scientific Computing for Image-based Systems Biology

›› visit the website of Ivo F. Sbalzarini Group

Research Avenue 6 RA1 RA3

Francis Stewart Group

TUD BIOTEC | Professor for Genomics

Epigenetic regulation and genomic engineering

›› visit the website of Francis Stewart Group

Research Avenue 1 RA5

Pavel Tomancak Group

MPI-CBG | Research Group Leader

Patterns of gene expression in animal development

›› visit the website of Pavel Tomancak Group

Research Avenue 5 RA1 RA2 RA3 RA4

Axel Voigt Group

TUD | Professor for Scientific Computing and Applied Mathematics

Mathematical Modeling and Numerical Simulation of Cells and Systems

›› visit the website of Axel Voigt Group

Research Avenue 1 RA6

Carsten Werner Group

IPF | Professor for Biofunctional Polymer Materials

Biofunctional polymer materials

›› visit the website of Carsten Werner Group

Research Avenue 6 RA1 RA3

Marino Zerial Group

MPI-CBG | Director of MPI-CBG, Professor for Cell Biology

Principles of cell and tissue organization: from endocytosis to a systems understanding of liver structure and function

›› visit the website of Marino Zerial Group

Research Avenue 2 RA1 RA3 RA6

Yixin Zhang Group

TUD B CUBE | Professor for Biomolecular Interaction

Drug design and screening: from biochemical methods to 3D model system

›› visit the website of Yixin Zhang Group