RA6 will develop complementary means to engineer and modulate living systems at the scales of molecules, cells and tissues, to exert exquisitely accurate and flexible control that will empower the investigation of biophysical mechanism. How can we remote-control force generation and self-organization? How can we develop systems where cytosolic phase transitions can be externally controlled? How can we design and control patterns of self-organization in cytoskeletal systems? How can we integrate our understanding of tissue-scale self-organization, and engineer morphogenesis? Research in RA6 will provide technical and conceptual advances for RA1-3 that enable accurate interrogation of the physical principles that underlie the dynamic spatiotemporal organization of living matter.

Optocontrollable proteins

Research Topic 1

Optocontrollable proteins

Designing cytoskeletal self-organization

Research Topic 2

Designing cytoskeletal self-organization

Control of cytosolic phase transitions

Research Topic 3

Control of cytosolic phase transitions

Engineering tissue morphogenesis

Research Topic 4

Engineering tissue morphogenesis