RA1 wants to unravel the principles by which mechanics and biochemical coupled in morphogenesis. We aim to reveal how the associated modules of self-organization are guided by physical cues and upstream signaling pathways. What are the mechanisms driving symmetry breaking in tissues and organisms? How do tissues size and shape themselves? How are tissue patterns generated and maintained? How are proportions maintained during growth? What makes a tissue fluid, what makes it contract? How do tissues buckle; how do they form three-dimensional shapes? What is the role of the Extracellular Matrix (ECM) in tissue morphogenesis? These questions will be addressed in the context of six research topics (RT) below.

Tissue self-organization

Research Topic 1

Tissue self-organization

Tissue left-right symmetry breaking

Research Topic 2

Tissue left-right symmetry breaking

Tissue size and scaling

Research Topic 3

Tissue size and scaling

Morphogen gradients

Research Topic 4

Morphogen gradients

Tissue contractility and fluidity

Research Topic 5

Tissue contractility and fluidity

Tissue folding

Research Topic 6

Tissue folding